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Is Cala Trio effective for medically refractory patients who develop coarse proximal tremors?

In clinical trials of Cala Trio, we did not specifically study medical refractory patients, or patients who show resistance to treatment. We studied two adjacently relevant characteristics.

  1. For patients on or off tremor medications, Cala therapy reduced tremor for both groups, and the improvements were not statistically different.
  2. Therapy reduced tremor whether patients reported previous ET treatment or not, and the improvements in these groups were not statistically different.


MKG-1050 Rev P Aug 2021